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Osteoarthritis; is the name of inflamed disease that occurs due to loss of cartilage in joints. It is the most common joint disease in human. Articular cartilage has a very limited capacity of repair. In order to be able to repair cartilage damage, chondrocytes which are cartilage cells starts to work by increasing their capacity. But if the cartilage damage is great and chronic, repair capacity of cartilage cells remains insufficient.

Glucosamine is necessary for production of cartilage. Glucosamine is an aminosaccharid and is an essential substance that is used for cartilage production by chondrocytes. It serves in formation reaction of glycosaminoglycans that are basic building structure of cartilage. Glucosamine prevents early cartilage damage by inhibiting enzymes which cause destruction of cartilage and it allows production of collagen.

 Chondroitin is the most abundant glycosaminoglycan in the body. It is an essential substance that is included in structure of proteoglycans that is necessary for cartilage production. Oral intake of chondroitin helps to stimulate cartilage production and prevents early destruction by inhibiting enzymes taking part in destruction of cartilage. Glucosamine and Chondroitin can prevent cartilage damage and stimulate cartilage production. In this way, they help to reduce chronic pain resulting from cartilage damage.

Methil Sulfonyl Methane (MSM) functions as a carrier molecule for elemental sulfur and this is necessary for amino acids methionine and cysteine. Amino acids are building blocks of proteins and proteins are necessary for growth and repair. MSM is beneficial for reducing inflammation and pain associated with osteoarthritis, rheumatoid arthritis, muscle pain, fatigue and back pain in joints. MSM relieves inflammation and pain by equalizing cell pressure.

Harpagophytum procumbens is used for elimination of back pain, symptomatic treatment of painful osteoarthritis and treatment of arthritis with its content of harpagoside and other iridoid glycosides. It is shown that herbal extracts of which inflammatory activity is put out by many surveys suppresses formation of prostaglandins that cause inflammation, pyogenesis, swelling and pain in joints and muscles and it may also suppress production of pro-inflammatory.

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